The HKα2-null mice had a Cryptocurrency exchange greater rate of fecal K+ excretion than the WT animals when fed a Na+-restricted diet. In addition, regardless of diet, the null mice exhibited smaller values of epithelial Na+ channel (ENaC)-mediated short-circuit current in the distal colon. The authors postulated that HKα2 plays an important role not only in K+ conservation but also in Na+ absorption by the colon, which suggests that HKα2 H+-K+-ATPase may also mediate Na+ reabsorption by the kidney. As noted above, dietary K+ depletion has been shown to produce a volume- and Na+-dependent form of hypertension despite reduction of plasma aldosterone concentration. Thus the precise cation specificity of the luminal and cytosolic binding sites of H+-K+-ATPase isoforms may have profound importance if the binding affinities differ between species.
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Pump
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